어스바이오는 Lumiprobe 한국 공식 대리점입니다.
어스바이오는 Lumiprobe 한국 공식 대리점으로서 모든 제품을 전문적으로 취급 및 공급하고 있습니다.
[Our PROTAC molecules for your targeted protein degradation]
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
Several types of E3 ligases are practically suitable for such a purpose. Thalidomide is a ligand capable of recruiting Cereblon (CRBN) E3 ligase. VHL Ligand 1 (VH032-NH2, (S, R, S)-AHPC) is a synthetic ligand for the von Hippel-Lindau (VHL) Cullin RING E3 ligase. We offer PROTAC building blocks containing different ligase recruiters and reactive groups for attaching the PROTAC molecule to the specific ligand of the target protein.
Product List
VHL ligand containing short carbon alkyl linker (C2) and terminal carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.Degrader building block containing an E3 ligase ligand with linker and amino group for conjugation with other functionalized linkers and target protein ligands.Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactionsThalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
어스바이오(USBIO)는 Lumiprobe 한국 공식 대리점입니다.
해당 제품에 대한 문의나 Lumiprobe 제품의 견적 또는 문의사항이 있으시면 아래로 연락주시기 바랍니다.
Tel: 02-862-2816 / Email: bio@usbio.co.kr
