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[Cloud-Clone 한국공식대리점] Apoptosis

작성자

관리자

작성일

2025-05-23

조회수

468

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[The key role and challenges of cell apoptosis in cancer treatment]

Apoptosis is a strictly regulated and evolutionarily conserved cell death program, also known for its role as a tumor suppressive mechanism. Apoptosis is a normal physiological cell death response to many stimuli, infections, or injuries, including those caused by cytotoxic drug therapy or radiation therapy regimens, which can result in irreparable DNA damage. The role of apoptosis in cancer has received widespread attention, and resistance to apoptosis is widely recognized as an acquired characteristic of cancer cells, giving them survival advantages, promoting tumor evolution and growth, and leading to treatment failure. Therefore, the efficacy of cancer treatment not only depends strictly on the cell damage they cause, but also on the ability of cells to activate their apoptosis program. In recent decades, research on cancer treatment has mainly focused on developing improved drugs and radiation therapy, aiming to induce maximum tumor cell death, thereby reducing tumor volume and blocking invasiveness.

1. Apoptosis and breast cancer

The clustering of death receptors (DRs) at the membrane leads to apoptosis.

2. Apoptosis and Colorectal cancer

Resistance to immunotherapy in colorectal cancer (CRC) is associated with obstruction of FAS (Apo‐1 or CD95)‐dependent apoptosis.

3. Apoptosis and bladder cancer

Molecular understanding of muscle-invasive (MIBC) and non–muscle-invasive (NMIBC) bladder cancer is currently based primarily on transcriptomic and genomic analyses.

4. Apoptosis and blood cancer

TP53-mutant blood cancers remain a clinical challenge. BH3-mimetic drugs inhibit BCL-2 pro-survival proteins, inducing cancer cell apoptosis.

References:

[1]Wang Y, Baars I, Berzina I, et al. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nat Nanotechnol. 2024. doi:10.1038/s41565-024-01676-4. (IF=38.1)

[2]Ma H, Suleman M, Zhang F, et al. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival. Adv Sci (Weinh). 2024;11(10):e2301476. (IF=14.3)

[3]Groeneveld CS, Sanchez-Quiles V, Dufour F, et al. Proteogenomic Characterization of Bladder Cancer Reveals Sensitivity to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand in FGFR3-mutated Tumors. Eur Urol. 2024;85(5):483-494. (IF=25.3)

[4]Diepstraten ST, Yuan Y, La Marca JE, et al. Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. Cancer Cell. 2024;42(5):850-868.e9. (IF=48.8)

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