[CellMosaic 한국공식대리점] AqueaTether® (AqT®) Technologies

CellMosaic is developing next-generation bioconjugation kits and products based on its proprietary super-hydrophilic and high-loading AqT linkers. AqT linkers are innovative, proprietary biomaterials developed at CellMosaic, featuring novel chemical architectures derived from a class of natural and edible sugar alcohol compounds. AqT molecules are specifically for labeling and conjugating biomolecules with highly hydrophobic small molecules, such as fluorescent compounds, biotin, and small-molecule drugs. Branched AqT® crosslinking reagents can also be customized to load a high amounts of detecting molecules onto a biomolecule for enhanced detection.

Sugar molecules are among the most hydrophilic natural compounds due to their hydrogen bonding capability (both donor and acceptor). Sugar alcohol, also known as polyol, is a hydrogenated form of carbohydrate in which the carbonyl group (aldehyde or ketone) has been reduced to a primary or secondary hydroxyl (OH) group. Sugar alcohols occur naturally in foods and are derived from plant products, such as fruits and berries. They are often used as ingredients in sweeteners and for producing polymers like hydrogel. 

CellMosaic has developed advanced methods to assemble highly sophisticated AqT® architectures from sugar alcohol monomers. Additionally, methods have been established to convert the OH groups of sugar alcohol into other crosslinking groups, such as aminooxy, maleimide, halide, azide, cyclooctyne, ketone, thioester, and N-hydroxysuccinimide ester (NHS). Table 1 lists some popular sugar alcohols used in the creation of AqT linkers.