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[어스바이오] BLDPharm 한국 공식 대리점 - 전문수입/통관

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2024-05-22
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어스바이오는 BLDPharm 한국 공식 대리점입니다.

어스바이오 공식 대리점 BLD Pharm의 새로운 소식을 전해드립니다.

NVS-STG2: A Molecular Glue-like Compound Opens a New Pathway for STING Activation
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Product Name : 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid
CAS No: 3030588-01-0
Cat. No: BD02516791
Molecular Weight : 427.53
MDL No: N/A
Purity/Specification: 98%
Molecular Formula: C25H33NO5
Storage: Keep in dark place, Sealed in dry, 2-8°C



STING (stimulator of interferon genes) is a dimeric transmembrane protein residing on the endoplasmic reticulum membrane. The discovery of agonists of the STING pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncology therapy.
Scientists from the University of Texas Southwestern Medical Center, in collaboration with Novartis, co-authored a paper titled "Activation of human STING by a molecular glue-like compound", which has been published in the journal "Nature Chemical Biology"



The research team conducted screening and identification on a specific compound library, ultimately identifying a lead compound. Through structural modification and chemical refinement, a more potent compound, NVS-STG2, was obtained. NVS-STG2 effectively serves as a molecular glue, strengthening the interface between two STING dimers, thereby promoting the higher-order oligomerization of human STING. The unique binding site of NVS-STG2 provides a new way to develop better STING agonists.



해당 제품에 대한 문의나 BLD Pharm 제품의 견적 또는 문의사항이 있으시면 아래로 연락주시기 바랍니다.
Tel : 02-862-2816 / email : bio@usbio.co.kr


 

 

 

 

 

 

 


 

 

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